新型生物材料聚(乳酸-蛋氨酸)的制备工艺研究  

Study on preparation of novel biomaterial poly(lactic acid-co-methionine)

作　　者：余世钦[1] 叶瑞荣[1] 杨利川[1] 李景宁[1] 汪朝阳[1] 

机构地区：[1]华南师范大学化学与环境学院化学系,广州大学城510006

出　　处：《现代化工》2009年第S2期88-90,共3页Modern Chemical Industry

基　　金：广东省自然科学基金博士科研启动基金(5300082)资助;国家自然科学基金(20772035)资助项目

摘　　要：以功能分子蛋氨酸改性聚外消旋乳酸(PDLLA),采用直接熔融聚合法合成了新型生物材料聚(乳酸-蛋氨酸)共聚物[P(LA-co-Met)],并用特性黏数、FT-IR1、H-NMR等手段对目标产物进行了表征。探讨了催化剂种类和用量、熔融聚合反应时间、反应温度等对P(LA-co-Met)合成的影响,得到最佳工艺条件为以SnCl2为催化剂(质量分数为0.5%),150℃、70 Pa下反应10 h,P(LA-co-Met)的特性黏数为0.9322 dL/g。Poly(D,L-lactic acid)(PDLLA) is modified by functional molecule methionine(Met),and a novel biomaterial poly(lactic acid-comethionine) [P(LA-co-Met)] is synthesized via direct melt polycondensation using D,L-lactic acid and Met as starting materials.The copolymer is characterized with intrinsic viscosity test,FT-IR,and 1H-NMR.The influences of different synthetic conditions,including kinds and quantity of catalyst,time and temperature of melt copolycondensation on the synthesis of P(LA-coMet) are discussed in detail.The optimal preparation conditions are obtained as follows:by using SnCl2(0.5 wt%) as catalyst,10 hours of polymerization under 150℃ and 70 Pa can give P(LA-co-Met) with maximum intrinsic viscosity of 0.9322 dL/g.

关 键 词：蛋氨酸 聚乳酸 熔融聚合 生物材料 制备 

分 类 号：R318.08[医药卫生—生物医学工程]