Mitotic chromosome mis-segregation mediated by Separase phosphosite mutation leads to aneuploidy and impaired oogenesis  

作　　者：Xingxu Huang, Meizhi Wang, Jingmei Chen National Resource Center for Mutant Mice, Model Animal Research Center of Nanjing University, 12 Xuefu Road, Pukou High-tech Development Zone, Nanjing 210061 

出　　处：《生物物理学报》2009年第S1期34-35,共2页Acta Biophysica Sinica

摘　　要：Aneuploidy is the leading genetic cause of human fertility failure. It is considered results from errors in meiotic and post-zygotic mitotic chromosome segregation. Using a

关 键 词：Mitotic chromosome mis-segregation mediated by Separase phosphosite mutation leads to aneuploidy and impaired oogenesis PGCs 

分 类 号：Q253[生物学—细胞生物学]