对乙酰氨基酚片含量测定结果的思考  

Discuss in the Analysis for the Content Determination of Paracetamol Tablets

作　　者：刘毅[1] 王天学[2] 魏文芝[2] 张娜[1] 

机构地区：[1]中国药品生物制品检定所,北京100050 [2]青海省药品检验所,西宁810000

出　　处：《中国现代应用药学》2009年第S1期1170-1171,共2页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的分析对比各国药典对乙酰氨基酚片的含量测定方法,以核查某批对乙酰氨基酚片含量测定的结果。方法用紫外E值法、紫外对照品法和HPLC对照品法3种药典方法分别核查了某批对乙酰氨基酚片含量测定的结果。结果该批次对乙酰氨基酚片的含量为90.5%,3种含量测定方法的检测结果相当。结论经过3种相对独立的药典含量测定方法相互验证,该批对乙酰氨基酚片含量测定结果准确、可靠。OBJECTIVE To check the result of the content determination of one certain batch of paracetamol tablets.METHODS Three methods in Pharmacopoeia,including reference substance comparison method,absorption coefficient method by UV,and content determination method by HPLC,were adopted to assay the content of the paracetamol tablets.RESULTS The content of the paracetamol tablets is 90.5% in reinspection,and the results of the three methods were equivalent.CONCLUSION The reinspection result has been proved by three individual methods each other,and the conclusion is accurate and reliable.

关 键 词：含量测定 对乙酰氨基酚 对乙酰氨基酚片 

分 类 号：R927.2[医药卫生—药学]