TOR信号转导通路介导的翻译控制  

Translation Control Regulated by TOR Signaling Pathway

作　　者：孙姝娟[1] 王雷[1] 

机构地区：[1]中国科学院海洋研究所,青岛266071

出　　处：《生物技术通报》2009年第S1期1-5,共5页Biotechnology Bulletin

摘　　要：TOR(target of rapamycin)是真核生物中高度保守的一种大分子的Ser/Thr激酶,是免疫抑制剂雷帕霉素的在体内的靶物质。TOR能够对营养状况和生长因子等因素的变化做出应答反应,通过介导磷酸化反应调节蛋白激酶4E-BP1,S6K, eEF2和磷酸酶等的活性,控制下游翻译因子的磷酸化水平,调节核糖体发生,蛋白质合成等生理过程,在细胞的生长,增殖的综合调控中起到中枢作用。Target of rapamycin(TOR) is a high conserved large Ser/Thr protein kinase in Eukaryotic.TOR is able to respond to change of such factors as nutrition and growth factors.Through mediating phosphorylation of protein kinase,such as 4E-BP1,S6K, eEF2,and the phosphates,TOR signaling pathway controls the phosphorylation of downstream translation factor,regulates ribosome biogenesis and protein translation,and plays a central role in regulating and integrating signals controlling cell growth,proliferation.

关 键 词：TOR 4E-BP S6K eEF2 Sit4 信号转导 翻译控制 

分 类 号：Q75[生物学—分子生物学]