诱导性多能干细胞(iPS)的应用和研究进展  

Progress and Application on Induced Pluripotent Stem Cell

作　　者：吴双[1] 张飞云[1] 

机构地区：[1]首都师范大学生命科学学院,北京100048

出　　处：《生物技术通报》2009年第S1期6-9,共4页Biotechnology Bulletin

基　　金：国家自然科学基金面上项目(30571010)

摘　　要：体外诱导人类体细胞转变为多能干细胞与传统的胚胎干细胞研究相比,相对简单,摆脱了材料来源和伦理学的诸多限制,因而引起了生命科学领域一次巨大的革命,尤其在医学上进步显著,被用于治疗遗传病、研究发病机制、利用患者自身细胞治疗疾病等方面。虽然目前对诱导性多能干细胞的应用和进展成果显著,但仍存在一系列亟待解决的问题,包括转变机理、安全性和效率低下等问题。本文重点阐述此项技术在医学上的应用和进展,以及仍然存在的问题和突破。In vitro induction of human somatic cells into pluripotent stem cells with the traditional embryonic stem cell research compared to relatively simple,breaking away from restrictions on source material and Ethics.Life sciences has aroused a great revolution, In particular of medicine.It is used for the treatment of genetic diseases,Study on the pathogenesis,using a patient's own cells to treat disease,and so on.Although the current—induced pluripotent stem cells in the outcome of applications and significant progress,there are still a number of problems calling for urgent solutions,Including the mechanism of cell transformation.Security and Inefficient.This article focuses on the technology applications in medicine and progress,as well as the problem still exists and breakthroughs.

关 键 词：诱导性多能干细胞 重编程 分化 

分 类 号：Q813[生物学—生物工程]