砂生槐种子水提物对S180荷瘤小鼠体内抗肿瘤作用  

Effect of SMSWE Anti-tumor on S180 Sarcoma in Mice

作　　者：贺学强[1] 郭君[2] 

机构地区：[1]中国人民解放军第181中心医院,广西桂林541002 [2]广西壮族自治区南溪山医院,广西桂林541002

出　　处：《中国中医药信息杂志》2009年第S1期20-21,共2页Chinese Journal of Information on Traditional Chinese Medicine

摘　　要：目的研究砂生槐种子水提取物的体内抗瘤作用,探讨其抗癌的药理机制。方法以S180荷瘤小鼠为研究对象,分别观察砂生槐种子水提取物各剂量组对S180荷瘤小鼠的抑瘤率、生存期、胸腺指数、脾脏指数、T淋巴细胞增殖活性。结果砂生槐种子水提取物1200、2400mg/kg剂量组的抑瘤率分别为34.9%、41.4%,与荷瘤对照组比较差异有统计学意义(P<0.05);小鼠平均存活时间与荷瘤对照组比较明显延长(P<0.01)。结论砂生槐种子水提取物能明显抑制S180小鼠体内肿瘤生长,并具有延长荷瘤小鼠生存期的作用。Objective To study the anti-tumor effect of water extracts from Sophora Moorcroftiana seed(SMSWE) in vivo on mice.Methods S180-bearing mice group were observed.The inhibitory rate of tumor,survival period,indexes of thymus and spleen,the proliferative ability of T lymphocytes were assayed.Results 1.2 and 2.4 g/kg SMSWE could inhibit the growth of S180 tumor in mice and prolonged survival period(P <0.05).SMSWE of 1.2 and 2.4 g/kg had inhibitory effects on tumor growth in inhibitory rate of 34.9% and 41.4%.Conclusion SMSWE could inhibit the growth of tumor and prolong the survival period of S180-bearing mice.

关 键 词：砂生槐种子水提取物 S180荷瘤小鼠 抗肿瘤 

分 类 号：R285.5[医药卫生—中药学]