乙酰水杨酸乙酯的合成及其体外抗菌效果的测定  

The synthesis and antibacterial effect determination of Acetylsalicylic acid ethyl ester

作　　者：裴海龙[1] 赵帆[1] 王希楠[1] 陈小玲[1] 黄建新[1] 

机构地区：[1]西北大学生命科学学院,陕西西安710069

出　　处：《云南大学学报（自然科学版）》2009年第S1期318-321,共4页Journal of Yunnan University(Natural Sciences Edition)

基　　金：国家大学生创新实验计划基金资助项目(200717)

摘　　要：合成乙酰水杨酸乙酯并评价其体外抗菌活性.用乙酰水杨酸和无水乙醇在1,4-二甲氨基吡啶催化下,合成目标化合物.用药敏纸片法确定目标化合物的抗菌活性.红外光谱分析和飞行时间质谱检测结果确定了乙酰水杨酸乙酯的化学结构,0.5g/L目标化合物质量浓度下对常见肠道致病菌的最大抑菌圈为16.10mm;1g/L目标化合物质量浓度下对常见肠道致病菌的最大抑菌圈为23.20mm.乙酰水杨酸乙酯确实有明显的体外抗菌活性,有开发利用的价值.To synthesize acetylsalicylic acid ethyl ester and evaluate its antibacterial activity.The target compound was synthesised under acetylsalicylic acid and ethanol in 1,4 -dimethyl aminopyridine catalyst. Drug-min paper aim to determine the antibacterial activity of compounds.The infrared chromatography mass spectrometry analysis and flight test results to determine the acetylsalicylic acid ethyl ester chemical structure.0.5g/L concentration of target compounds of the largest common intestinal pathogenic bacteria inhibition zone for 16.10mm; 1g/L concentration of target compounds under the common intestinal pathogenic bacteria inhibition zone for the maximum 23.20mm.Acetylsalicylic acid ethyl ester indeed has a clear antibacterial activity,it has the value of development and utilization.

关 键 词：乙酰水杨酸乙酯 红外光谱 飞行时间质谱 药敏纸片法 

分 类 号：R96[医药卫生—药理学] TQ245.24[医药卫生—药学]