HBeAg阴性慢性HBV感染者肝组织病理分析  

Pathological Analysis of Liver Biopsies in Patients with HBeAg-negative Chronic HBV Infection

作　　者：迟晓伟[1] 戈国亮[1] 杨微波[1] 范晶华[1] 张艳梅[1] 陈一晖[1] 

机构地区：[1]昆明医学院第一附属医院感染科,云南昆明650032

出　　处：《昆明医科大学学报》2009年第S2期26-28,共3页Journal of Kunming Medical University

摘　　要：目的了解HBeAg阴性、ALT小于2倍正常值上限(ULN)的慢性HBV感染者肝组织病理学特点.方法451例ALT<2×ULN的慢性HBV感染者被分为HBeAg阳性组及HBeAg阴性组,进行肝活检及病理炎症、纤维化分级、分期诊断,比较两组间差异.结果HBeAg阴性慢性HBV感染者炎症分级G2以上占46.3%,HBeAg阳性慢性HBV感染者炎症分级G2以上占45.9%,两组比较差异无统计学意义(P>0.05).结论HBeAg阴性、ALT<2×ULN的慢性HBV感染者仍应按指南要求进行肝活检指导抗病毒治疗.Objective To understand the characteristics of the liver histopathology of the chronic HBV infectors with negative HBeAg and ALT is less than two times of the normal value ceilings(ULN).Methods 451 cases of ALT<2×ULN chronic infectors were divided into two groups,one with positive HBeAg and the other with negative HBeAg.Differences between the two groups were compared in liver biopsy,pathological inflammation,stage of fibrosis and staging diagnosis.Results There was 46.3% negative chronic HBV infectors with inflammation graded above G2,and the percentage for the positive chronic HBV infectors was 45.9%.There was no statistically significance for the comparison between the two groups(P>0.05).Conclusion Chronic HBV infectors with negative HBeAg,ALT<2×ULN should still be treated with antiviral therapy under the liver biopsy guidance according to the guidelines.

关 键 词：HBEAG 携带者 慢性乙型肝炎 肝活检 病理 

分 类 号：R512.62[医药卫生—内科学] R450[医药卫生—临床医学]