脂肪间质干细胞在心肌缺血性疾病中的应用  

Application of Adipose Tissue-derived Mesenchymal Stem Cells in Myocardial Ischemia Disease

作　　者：张雅永[1] 蒋立虹[1] 侯宗柳[1] 

机构地区：[1]昆明医学院附属延安医院心胸外科,云南昆明650051

出　　处：《昆明医科大学学报》2009年第S2期46-49,共4页Journal of Kunming Medical University

基　　金：云南省社会发展科技计划资助项目(2007CA005)

摘　　要：脂肪间充质干细胞来源于脂肪组织,易于体外分离培养,大量扩增.很多临床前及临床研究已经证实其可以通过分化为心肌样细胞,促血管生成、旁分泌等作用参与心肌梗死后组织修复,改善心脏功能.脂肪间充质干细胞是理想的心肌再生治疗的细胞来源.就相关领域研究现状及进展作一综述.Adipose tissue-derived Mesenchymal stem cells(Ad-MSCs)are present in adipose tissue,from which they can be easily isolated and cultured ex vivo.Several preclinical and clinical studies have supported the notion that therapy using MSCs may be applicable for:myocardial repair,improving ventricular function mediated through differentiating into myocardial-like cells,and angiogenesis or paracrine effects.Overall Ad-MSCs are nil attractive cell population for cardiovascular repair.This paper reviews the current status of the use of Ad-MSCs,and advances in related areas.

关 键 词：间质干细胞 间质干细胞移植 缺血性心肌病 脂肪组织 

分 类 号：R329[医药卫生—人体解剖和组织胚胎学]