表观遗传修饰与脊髓可塑性  

Epigenetic Modification and Spinal Cord Plasticity

作　　者：张志萍 李力燕[1] 王廷华[1] 

机构地区：[1]昆明医学院神经科学研究所,云南昆明650031

出　　处：《昆明医科大学学报》2009年第S2期186-189,共4页Journal of Kunming Medical University

摘　　要：脊髓可塑性是脊髓损伤恢复的基础.近来研究显示表观遗传修饰通过动态调控基因表达介导神经可塑性与环境刺激之间的协调.认识这些机制可能有助于发现提高脊髓可塑性的新策略.就表观遗传修饰和脊髓可塑性的关系作一综述.Spinal cord plasticity underlie recovery from spinal cord injury.Recent evidence suggests that the dynamic regulation of gene expression through epigenetic mechanisms is at the interface between environmental stimuli and neuronal plasticity.Understanding these mechanisms may provide new strategies for increasing spinal cord plasticity.In this review,we will discuss the relation between epigenetic modification and spinal cord plasticity.

关 键 词：表观遗传修饰 表观遗传学 脊髓可塑性 脊髓损伤 

分 类 号：R651.2[医药卫生—外科学]