细胞因子在登革病毒致病机制中的作用研究进展  

Advances in Role of Cytokines in Immune Pathogenesis of Dengue Virus Infection

作　　者：王晴晴[1] 游晶[1] 冯霞[1] 杨瑞冬[1] 陈红英[1] 

机构地区：[1]昆明医学院第一附属医院感染病科,云南昆明650032

出　　处：《昆明医科大学学报》2009年第S2期297-301,共5页Journal of Kunming Medical University

摘　　要：登革病毒(DV)感染包括登革热(DF)、登革出血热(DHF)和登革休克综合征(DSS),广泛流行于全球热带和亚热带地区,是分布最广,发病最多,危害较大的虫媒病毒性疾病,近年已成为一个主要的国际公共卫生问题.WHO估计,每年全球有5000万DV感染病例,病死率约5%,DHF/DSS的病死率可达20%～30%.DF及DHF/DSS发病机制一直是国内外研究的重要热点,但至今尚未完全阐明.近年研究表明,DV的致病与细胞因子释放有密切关系.Infection of human beings with dengue virus results in dengue fever(DF)and severe syndrome-dengue haemorrhagic fever(DHF)and dengue shock syndrome(DSS),with widely prevalence in tropical and sub-tropical regions that circle the globe.It,with the most widely distribution and topmost incidence,is of imperil vector viral disease.Nowadays,it has become a main international public health problem.WHO estimates that about 50～100 million individuals are infected every year worldwide with an overall mortality rate of 5% and,for DHF/DSS range from 20% to 30%.The research on the pathogenesis of DF and DHF/DSS is an important hotspot,whereas still remain unclear.In recent years,studies have shown that the pathogenicity of the virus is correlated with cytokine release.

关 键 词：登革病毒 致病机制 细胞因子 

分 类 号：R373.33[医药卫生—病原生物学]