早期应用足量纳洛酮治疗颅脑损伤的临床疗效观察  

Clinical Observation of Craniocerebral Injury Application with Naloxone in Early Adequate Treatment

作　　者：兰荣宝[1] 仇洪[1] 张传东[1] 蒙海滨[1] 刘军[1] 兰展 罗铸[1] 

机构地区：[1]广西河池市人民医院神经外科,广西河池547000

出　　处：《航空航天医学杂志》2009年第10期43-44,共2页Journal of Aerospace medicine

摘　　要：目的:观察早期足量应用纳洛酮治疗颅脑损伤的临床疗效。方法:将纳入的颅脑损伤患者66例以随机数字表法分为实验组(n=33)及对照组(n=33),两组均给予常规治疗,实验组在此基础上加用纳洛酮注射剂体重,用500 m l乳酸钠林格氏液稀释后微量注射泵持续静滴24h,连用7 d后减量为4.8 mg/d,继续应用3 d后停药。两组总疗程均为10 d。比较两组患者入院时及治疗10 d后的格拉斯哥评分(GCS)计分和随访6个月的格拉斯哥预后评分(G0S)计分,以及治疗前后β内啡肽(β-EP)浓度变化。结果:治疗10 d后,两组患者GCS计分与治疗前比较均有显著性差异(P<0.05),且实验组患者治疗10 d后GCS计分与对照组比较差异有统计学意义(P<0.05);治疗后两组患者的β-EP浓度与治疗前相比均明显降低,差异有统计学意义(P<0.05),两组比较差异有统计学意义(P<0.05)。6个月后G0S计分两组比较有显著性差异(P<0.05)。结论:早期足量使用纳洛酮治疗颅脑损伤可以促进患者清醒和脑功能恢复,保护中枢神经系统。Objective:To observe the early application of adequate treatment of craniocerebral injury naloxone clinical efficacy.Methods:Otal course of the two groups were 10 d.Comparison of two groups of patients on admission and treatment of 10 d after the Glasgow score(GCS) score and follow-up 6 months of Glasgow outcome score() scoring,as well as before and after treatment of β-endorphin(β-EP) concentration.Results:After 10 d,two groups of patients with GCS score before treatment were significantly different(P<0.05),the experimental group and 10 d after treatment in patients with GCS score compared with the control group were statistically significant differences(P<0.05);the two groups after treatment in patients with β-EP concentrations compared with those before treatment were significantly reduced,the difference was statistically significant(P<0.05),difference between the two groups was statistically significant(P<0.05).6 months after G0S comparison of two groups were significantly different(P<0.05).Conclusion:Early adequate treatment of the use of naloxone in patients with craniocerebral injury can promote a clear and brain function,protect the central nervous system.

关 键 词：纳洛酮 颅脑损伤 Β内啡肽 

分 类 号：R651.15[医药卫生—外科学]