乙肝患者体内HBV复制与肝损伤的相关性探讨  

Investigation of the correlation between the HBV replication and liver damage in patients with hepatitis B

作　　者：陈克平[1,2] 苏青霞 陈飞[4] 徐白泉 李丽[1] 卢慧霞[1] 

机构地区：[1]东南大学附属中大医院,南京210009 [2]东南大学发育与人类疾病相关基因教育部重点实验室 [3]忻州市人民医院 [4]东南大学临床医学院检验系

出　　处：《山东医药》2009年第51期33-34,共2页Shandong Medical Journal

摘　　要：目的探讨乙型肝炎(乙肝)患者体内病毒复制与肝损伤的关系。方法取400份住院乙肝患者血清,测定HBV-DNA水平、乙肝病毒血清标志物(HBV-M)及肝功指标ALT及AST。分析各指标间的相关性。结果HBeAg阳性患者HBV-DNA水平明显高于HBeAg阴性患者,P<0.05;二者的HBV-DNA水平与ALT及AST均无显著差异;大三阳与小三阳患者HBV-DNA水平与ALT及AST亦均无显著性差异。结论乙肝患者HBV-DNA水平与肝损伤程度无明显相关性。objective To investigate the correlation between the HBV replication and liver damage in patients with hepatitis B.Methods Serum from 400 patients with hepatitis B were collected,then the HBV DNA level,hepatitis B virus markers(HBVm)and ALT ,AST level were detected ,the correlation among the indicators were analyzed. Results HBV DNA levels in HBeAg(+)patients were significantly higher than that in HBeAg(-) patients. But no significant difference of ALT or AST levels were found between the HBeAg(+) and HBeAg(-)patients.There were no significant difference of HBV-DNA,ALT and AST levels between the patients with HBsAg(+)+HBeAg(+)+anti-HBc(+)and HBsAg(+)+anti-HBe (+)+anti-HBc(+). Conclusion There is no significant correlation between the serum HBV-DNA level and the degree of liver damage.

关 键 词：乙型肝炎病毒-DNA 乙型肝炎病毒血清标志物 丙氨酸氨基转移酶 天门冬氨酸氨基转移酶 

分 类 号：R512.62[医药卫生—内科学]