Npt、IL-8和HCY与冠心病的关系  

Relationship between neopterin,interleukin-8,homocysteine and coronary heart disease

作　　者：王钢[1] 庞沛[2] 张军[1] 赵荣诚[1] 袁琛[1] 韩立宪[1] 

机构地区：[1]沧州市中心医院,河北沧州061001 [2]沧州医学高等专科学校

出　　处：《山东医药》2009年第52期34-36,共3页Shandong Medical Journal

摘　　要：目的研究新蝶呤(Npt)、白细胞介素8(IL-8)和同型半胱氨酸(HCY)与冠心病患者冠状动脉病变稳定性及病变狭窄程度的关系。方法选取不稳定型心绞痛(UAP)和稳定型心绞痛(SAP)患者各30例,另20例冠脉造影正常者为正常对照组,ELISA法测定Npt、IL-8、HCY水平,均接受冠状动脉造影,根据冠状动脉狭窄程度及部位进行记分。结果心绞痛患者Npt、IL-8、HCY均较正常对照组增高(P均<0.05),且UAP较SAP的Npt、IL-8、HCY升高更明显(P均<0.05)。冠状动脉三支病变组Npt、IL-8、HCY的水平高于双支病变组和单支病变组,且3组均高于对照组。Npt、IL-8、HCY是UAP和冠状动脉狭窄程度的独立危险因素。结论Npt、IL-8、HCY可作为判定冠心病患者冠状动脉病变稳定性和狭窄程度的指标。Objective To investigate the relationship between neopterin(Npt),interleukin-8(IL-8),homocysteine(HCY) and stability of coronary lesions,severity of coronary stenosis in coronary heart disease(CHD).Methods Npt,IL-8 and HCY levels were measured with ELISA in 80 patients,including 30 patients with unstable angina(UAP),30 patients with stable angina(SAP) and 20 patients with normal coronary angiography(control group).All patients received coronary angiography and were evaluated according to the degree of coronary stenosis.Results The level of IL-8,Npt,HCY in angina patients were higher than those in control group,and all of them in UAP group were higher than those in SAP group.The levels of Npt,IL-8 and HCY in patients with triple-vessel lesions were higher than those with single-vessel or double-vessel lesions,and they were higher than those in control group.Npt,IL-8 and HCY were independent risks for the stability of lesions and the severity of stenosis in CHD patients.Conclusion Npt,IL-8 and HCY might be the predictors of stability and severity of coronary lesions in CHD.

关 键 词：冠状动脉疾病 新蝶呤 白细胞介素8 半胱氨酸 

分 类 号：R541.4[医药卫生—心血管疾病]