黑色素瘤抗原-A10蛋白在肺癌中的表达及意义  

Expression of MAGE-A10 protein and its clinical significance in human lung cancer

作　　者：李林[1] 陈丽华[1] 庄然[1] 方亮[1] 李琦[1] 刘雪松[1] 王薇[1] 杨安钢[1] 金伯泉[1] 

机构地区：[1]第四军医大学免疫学教研室,陕西西安710032

出　　处：《医学研究生学报》2004年第6期493-495,F003,共4页Journal of Medical Postgraduates

摘　　要：目的 :观察黑色素瘤抗原 (MAGE) A10在不同类型肺癌的表达分布和临床意义。　方法 :应用组织芯片技术、免疫组化S P法研究MAGE A10在 6 5例肺癌患者的表达情况 ,并分析其与病理类型、病理分级的关系。　结果 :MAGE A10蛋白在小细胞肺癌、肺鳞癌和肺腺癌的阳性表达率分别为 36 .4 %、76 .5 %和 4 0 .0 % ,在大细胞肺癌和支气管肺泡癌中未见阳性表达。MAGE A10蛋白在小细胞肺癌与非小细胞肺癌的表达率未见差异 ,与肺鳞癌、肺腺癌的病理分级也无明显关系。　结论 :MAGE A10分子在肺鳞癌中表达率最高 ,肺腺癌和小细胞肺癌次之 ,大细胞肺癌和支气管肺泡癌中未见表达 ,对鉴别诊断可能有辅助意义 ,并可能成为某些肺癌生物学治疗的潜在靶点。Objective: To explore the expression and the clinical significance of MAGE-A10 in human lung cancer. Methods: By using tissue array and S-P immunohistochemical methods with anti-MAGE-A10 monoclonal antibody, the expression of MAGE-A10 protein in 65 cases lung cancer was investigated and the correlation of MAGE-A10 expression with histological types and pathological grades was also evaluated. Results: The positive expression rates of MAGE-A10 were 36.4% in small cell lung carcinoma, 76.5% in squamous cell lung carcinoma and 40.0% in lung adenocarcinoma repectively, but no positive case can be found in large cell lung carcinoma and bronchioloalveolar carcinoma. It was no statistical significance between the expression ratio of MAGE-A10 protein in the small cell lung carcinoma(SCLC) and non-small cell lung carcinoma(NSCLC). The correlation of pathological grades in both the squamous cell carcinoma groups and the adenocarcinoma groups with expression of MAGE-A10 was also not been found. Conclusion: The expression ratio of MAGE-A10 in squamous cell lung carcinoma was the highest, followed by that in lung adenocarcinoma and SCLC suggesting that MAGE-A10 might be used as an useful marker in pathological diagnosis as well as a potential target in biological therapy of lung cancer.

关 键 词：黑色素瘤抗原-A10 肺癌 免疫组化 组织芯片 

分 类 号：R239[医药卫生—中医学]