精神分裂症患者词语流畅性作业测验的功能MRI研究  

Functional magnetic resonance imaging of schizophrenic patients and comparison subjects during a verbal fluency task

作　　者：刘含秋[1] 冯晓源[1] 刘登堂[2] 黎元[1] 汤伟军[1] 

机构地区：[1]复旦大学华山医院放射科,上海200040 [2]复旦大学华山临床医学院精神病学教研室

出　　处：《中华放射学杂志》2004年第6期578-581,共4页Chinese Journal of Radiology

摘　　要：目的　应用功能磁共振成像研究正常人和精神病患者在进行词语流畅作业测验时其额、颞叶皮层激活情况的差异。方法　 8位志愿者和 13名精神分裂症患者接受词语流畅作业测验。受试者执行任务时 ,应用GE 1 5TSignaHorizonLX超导型磁共振仪 ,采集其脑部的血氧水平依赖 功能磁共振成像 (BOLD fMRI)数据。刺激序列被分成 6个时相 ,每个时相 30s ,通过使用Block激活模式 ,即休息和刺激状态交替。结果　对两组额叶、颞叶激活区面积 (包括额上回、额中回及额下回 )和激活区出现比例 (包括颞上回、颞中回及颞下回 )进行比较 ,精神分裂症组左侧额叶激活较正常组的明显减少 ;正常组左侧额叶较右侧有明显增加 ,P <0 0 5。而颞叶各脑回的精神分裂症患者与正常对照组及左右各对应脑回之间激活情况相仿 ,P <0 0 5。结论　fMRI对检测对照组和精神分裂症患者之间完成高级认知作业时的大脑皮层激活差异具有重要价值。Objective To study the changes in cortical activation of frontal lobes and temporal lobes between schizophrenic patients and comparison subjects during a verbal fluency task by using functional magnetic resonance imaging (fMRI). Methods Thirteen schizophrenic patients and 8 volunteers were studied during a verbal fluency task performance. fMRI of frontal lobes and temporal lobes was conducted at a GE 1.5 T Signa Horizon LX scanner while the subjects performed the task. Stimulus sequences were divided into six 30-second segments by using a task-activation paradigm that alternated between resting and stimulated states. Results Schizophrenic subjects demonstrated significantly less left frontal activation than comparison subjects during a word fluency task, and comparison subjects showed evidently more activation in left frontal lobes than in the right (P<0.05). But there was no significant difference of the temporal activation between the two groups (P>0.05). Conclusion These preliminary data suggest that fMRI has the sensitivity to detect the differences in activation between comparison subjects and schizophrenic patients during higher cortical functions.

关 键 词：精神分裂症 词语流畅性作业测验 功能 MRI 评价研究 

分 类 号：R445.2[医药卫生—影像医学与核医学]