HIV慢性感染者总淋巴细胞计数与CD4^+细胞计数相关性研究  

Correlation of Total Lymphocyte Counts with CD4^+ Counts among HIV-positive Former Blood Donors in Anhui Province

作　　者：张言敏[1] 谷永斌[2] 徐正厚 丁心平 徐臣 高冰 韩丽凤[1] 彭红[1] 祝婷[1] 王建军[5] 苏斌[5] 刘清芳[6] 阮玉华[1] 徐建青[1] 邵一鸣 

机构地区：[1]中国疾病预防控制中心性病艾滋病预防控制中心传染病预防控制国家重点实验室 [2]安徽省阜阳市阜南县疾病预防控制中心 [3]安徽省阜阳市颍州区疾病预防控制中心 [4]安徽省阜阳市疾病预防控制中心 [5]安徽省疾病预防控制中心 [6]苏州大学

出　　处：《中国病毒病杂志》2008年第3期161-164,共4页Chinese Journal of Viral Diseases

基　　金：美国国立卫生研究院资助项目(中国综合性艾滋病研究项目;U19AI51915);国家"十五"科技攻关项目(2004BA719A01)

摘　　要：目的评价安徽省阜阳市HIV感染既往献血人群总淋巴细胞计数和CD4+细胞计数间的相关性。方法于2005年6～8月,对安徽省阜阳市HIV感染既往献血员进行横断面调查,对符合条件的279名研究对象分别进行总淋巴细胞计数和CD4+细胞计数检测,利用SAS软件对279组数据进行相关性分析,同时根据SPSS软件计算所得的灵敏度、特异度和准确性(ROC面积)来寻找能有效预测CD4+细胞计数<0.2×109/L与<0.35×109/L的总淋巴细胞的范围。结果调查对象总淋巴细胞计数和CD4+细胞计数之间存在相关性(r=0.53,P<0.01),总淋巴细胞<1.4×109/L对应于CD4+细胞计数<0.2×109/L有70.6%的灵敏度,69.7%的特异度,(0.833±0.067)的准确性(ROC面积);总淋巴细胞<1.6×109/L对应于CD4+细胞计数<0.35×109/L有73.3%的灵敏度,63.6%的特异度,(0.712±0.031)的准确性(ROC面积)。结论在资源有限的国家和地区可利用总淋巴细胞计数作为CD4+细胞计数的一项替代指标,来预测了解HIV感染者的疾病进展状况(<0.35×109/L或<0.2×109/L)及指导临床治疗。Objective To estimate the correlation of total lymphocyte counts with CD4+ counts among HIV-positive former blood donors in Fuyang of Anhui province,China.Methods From June to August,2005,a cross-sectional study was conducted among HIV-positive former blood donors in Fuyang of Anhui province.The total lymphocyte counts and CD4+ counts of 279 participants were tested.The correlation of total lymphocyte counts with CD4+ counts was analyzed.Results The correlation between 279 paired total lymphocyte counts and CD4+ counts was found(r=0.53,P<0.01).Total lymphocyte counts <1.4×109/L was 70.6% sensitive and 69.7% specific for CD4+ <0.2×109/L,and the area under the ROC curve was(0.833±0.067);Total lymphocyte counts<1.6×109/L was 73.3% sensitive and 63.6% specific for CD4+<0.35×109/L,and the area under the ROC curve was(0.712±0.031).Conclusion Total lymphocyte counts can be available as a substitute method to estimate AIDS progression(<0.35×109/L or <0.2×109/L) and monitor antiretroviral therapy in some resource-constrained countries and regions.

关 键 词：艾滋病病毒 既往献血员 总淋巴细胞计数 CD4^+计数 

分 类 号：R512.91[医药卫生—内科学]