湖北地区人畜共患病戊肝病毒在不同人群中的流行病学研究  

Prevalence of Anti-HEV Antibody among Different Population Groups in Hubei Province

作　　者：刘小桂 李秀纪[2,3] 陈平 宋爱京[2] 罗静 樊金萍[2] 罗一红 刘利铭 赵晨燕[2] 章金刚[3] 牛丽莉 王汉华 许四宏[2] 王佑春[2] 

机构地区：[1]湖北出入境检验检疫局,武汉430000 [2]中国药品生物制品检定所细胞室 [3]军事医学科学院野战输血研究所

出　　处：《中国病毒病杂志》2008年第5期321-324,共4页Chinese Journal of Viral Diseases

基　　金：国家863课题(2006AA02Z453);国家质量监督检验检疫总局科研基金项目(2007IK206)

摘　　要：目的调查湖北地区不同人群中戊型肝炎病毒(HEV)感染情况和流行特征,为控制HEV在人畜间的传播提供依据。方法采集养猪场从业人员472人,屠宰场从业人员313人,农民168人,农民工300人,义务献血员500人和学生98人的血清样品共计1 851份。用酶联免疫吸附实验(ELISA)检测抗-HEV IgG抗体,用统一制定的流行病学调查表进行分析。结果养猪场从业人员和农民中抗-HEV抗体阳性率分别为55.72%和53.57%,明显高于屠宰场从业人员、农民工、学生和义务献血人员中的阳性率,分别为31.63%,30.67%,27.55%和33.40%,且差异有统计学意义,(x^2=44.19,P<0.01)。养猪场和屠宰场从业人员从业年限在10年以下和10年以上的抗- HEV抗体阳性率差异均有统计学意义(P<0.05)。养猪场和屠宰场从业人员、农民及农民工的抗-HEV抗体阳性率均与年龄有关,其中养猪场从业人员、农民和农民工的抗-HEV抗体阳性率均随年龄的增长呈上升趋势。结论与猪特别是与幼猪接触越密切以及强度越大的人群,其抗-HEV抗体阳性率也越高,提示猪是HEV的主要传染源之一。Objective To investigate the prevalence of anti - HEV antibody among different population groups in Hubei province and provide scientific data for prevention of HEY spread among personnels and animals.Methods The anti-HEV IgG in 1 851 serum specimens collected from different population groups was detected by ELISA.The personal informations of dif- ferent population groups were collected on the spot for the epidemiological analysis.Results The positive rates for anti - HEV antibody of the workers at pig farms (55.75%) and peasants (53.57%) were significantly higher than those in the workers at slaughter company,farmers - turned migrant workers,students and blood donors (they were 31.63%,30.67%,27.55% and 33.40% respectively)(x^2=44.19,P<0.01).The positive rates for anti-HEV antibody were significantly higher in pig farm and slaughter company workers working for more than I0 years (63.50%) than those working less than 10 years (41.51%) (x^2=23.23,P<0.01).The positive rates for anti-HEV antibody were related to ages among the workers at pig farm,slaugh- ter company,farmers-turned migrant workers and peasants,which were increased with aging.Conclusion The more closely and frequently the persons contacted with pigs,the higher the prevalence of anti-HEV antibody was among them.Thus pigs may be one of the main source for transmitting HEV.

关 键 词：戊型肝炎病毒 抗体 人群 流行病学 

分 类 号：R181.3[医药卫生—流行病学]