美托洛尔对高血压及冠心病患者空腹血糖的影响  

Effects of Metoprolol on glucose in the treatment of essential hypertension and coronary arterial disease

作　　者：李晓丽[1] 梅霞[1] 

机构地区：[1]重庆市中山医院心内科,400013

出　　处：《中国医药指南》2008年第24期23-,25,共2页Guide of China Medicine

摘　　要：目的回顾分析老年高血压及冠心病患者(65～80岁)使用美托洛尔后对空腹血糖、餐后2h血糖及糖化血红蛋白水平的影响。方法随机选择过去3年反复在本科住院且长期在本院门诊随访、依从性好、长期使用美托洛尔的老年患者(排除本身已有血糖异常、肾功能不全、心功能不全、支气管哮喘及高血压中使用利尿剂的患者),分为小剂量美托洛尔组(服用美托洛尔≤200mg/d)、大剂量美托洛尔组(服用美托洛尔>200mg/d)及对照组(未使用美托洛尔),各组分别为74、30、51例患者。结果与结论服用小剂量美托洛尔的患者空腹血糖、餐后2h血糖及糖化血红蛋白无明显升高,而大剂量者(>200mg/d)空腹血糖与糖化血红蛋白明显升高。Objective This study was to determine the effect of treatment metoprolol on fasting blood glucose,postprandial blood glucose,and glycosylated hemoglobin in cases with essential hypertension and coronary arterial disease.Methods Randomly chose the old patients who used metoprolol regular with good compliance,excluding those with abnormal blood glucose,renal insufficiency, heart failure,bronchial asthma and using diuretic.All the patients were divided into low dose of metoprolol group(≤200mg/day),heavy dose of metoprolol group(>200mg/day),and contrast group.Results and Conclusion Blood glucose level and glycosylated hemoglobin increased obviously in heavy dose of metoprolol group than in low dose group.

关 键 词：美托洛尔 空腹血糖 糖化血红蛋白 

分 类 号：R544.1[医药卫生—心血管疾病] R541.4[医药卫生—内科学]