新兵接种乙型肝炎疫苗快速免疫程序和两针免疫程序的效果比较  

Study on immunogenicity of hepatitis B vaccine by accelerated schedule or by two-dose schedule

作　　者：袁跃彬 朱结根 段新科 王仲倩 

机构地区：[1]解放军152中心医院传染科 [2]河南信阳71872部队卫生队

出　　处：《第四军医大学学报》2004年第11期1042-1044,共3页Journal of the Fourth Military Medical University

摘　　要：目的 :研究新兵采用快速免疫程序或两针免疫程序的免疫效果 ,为丰富军人乙肝免疫策略提供依据 .方法 :1 5 0名符合要求的新兵随机分为A ,B ,C三组 ,分别按标准免疫成序、快速免疫程序、两针免疫程序接种乙肝疫苗 ,每次均为 1 0μg.结果 :首针免疫后 1mo时B组的血清抗 HBs阳转率 (6 4 .0 % )高于A组 (2 6 .0 % ,P <0 .0 1 )和C组 (2 8.0 % ,P <0 .0 1 ) ,首针免疫 7mo和 1 2mo时三组间抗 HBs阳性率无显著性差异(P >0 .0 5 ) ;同时 ,首针免疫后 1mo时 ,B组的抗 HBs几何平均滴度 (GMT)高于A组和C组 (P <0 .0 1 ) ,3mo时 ,B组的抗 HBs几何平均滴度仍高于A组和C组 (P <0 .0 1 ) ,7mo时A组的抗 HBs几何平均滴度高于B组和C组 (P <0 .0 1 ) .结论 :和标准免疫程序相比 ,快速免疫程序能较早地产生保护性抗体 ,两针免疫程序经济、有效 。AIM: To study the immunogenicity of hepatitis B vaccine by accelerated schedule or by two dose schedule. METHODS: One hundred and fifty subjects were randomly divided into A, B and C groups and were vaccinated by standard schedule, accelerated schedule or two dose schedule, respectively. The antibody response was determined at 1st month, 3rd month, 7th month and 12th month. RESULTS: One month after the first vaccine injection, the seroconversion rate of group B (64.0%) was higher than that of group A (26.0%, P <0.01) or that of group C (28.0% , P <0.01), and the mean geometric titer (GMT) of group B was higher than that of group A or group C ( P < 0.01) . So was the case at 3rd month. At 7th or 12th month, the seroconversion rates had no difference between the three groups, but at 7 month, the GMT of group A was higher than group B or group C. CONCLUSION: Accelerated schedule provides protective antibody titers with a shorter time compared to the standard schedule, and the two dose schedule is cost effective in achieving protective immuogenicity.

关 键 词：乙型病毒性肝炎 免疫接种程序 抗体几何平均滴度 

分 类 号：R512.6[医药卫生—内科学]