心脏发育中的细胞凋亡  

Apoptosis in Cardiac Development

作　　者：杨鸿[1] 王跃群[1] 吴秀山[1] 

机构地区：[1]湖南师范大学生命科学学院蛋白质化学与发育生物学教育部重点实验室,中国湖南长沙410081

出　　处：《生命科学研究》2002年第S2期62-65,共4页Life Science Research

基　　金：国家自然科学基金资助项目(30170479);湖南省特聘教授基金资助项目(25000613);教育部重点课题项目

摘　　要：重点讨论了心脏发育过程中主要的细胞凋亡以及信号串级联,这些信号串往往伴随着有序的形态学上的事件.细胞凋亡主要发生在胚胎心脏中非心肌的隔室中,其隔室由心内膜、心外膜和神经嵴衍生的细胞组成.这些信号的级联包含了潜在生长转化因子的激活,导致心肌细胞的迁移以及随后的心内膜垫的心肌化.错误的细胞凋亡将导致心脏发育的异常.Apoptosis in cardiac development and subsequent signal cascades in combination with timed morphogenetic events are reviewed. Apoptosis mainly occurs in the nonmyocardial compartment of the embryonic heart, a compartment that consists of cells derived from the endocardium, the epicardium and the neural crest. The signalling cascade seems to involve the activation of latent transforming growth factor beta, resulting in cardiomyocyte migration and subsequent myocardialization of the endocardial cushions. Aberrant apoptosis accompanies cardiac anomalies.

关 键 词：心脏 发育 细胞凋亡 

分 类 号：Q255[生物学—细胞生物学]