脊椎动物心脏形态发育的转录调控  

Transcriptional Regulation of Vertebrate Cardiac Morphogenesis

作　　者：吴红霞[1] 李永青[1] 吴秀山[1] 

机构地区：[1]湖南师范大学生命科学学院蛋白质化学与发育生物学教育部重点实验室,中国湖南长沙410081

出　　处：《生命科学研究》2002年第S2期101-105,共5页Life Science Research

基　　金：国家自然科学基金资助项目(30170479);湖南省特聘教授基金资助项目(25000613);教育部重点课题项目

摘　　要：转录因子以组织特异性和数量的方式调节基因的表达,是胚胎发育中的主要调节因子.目前已经鉴定了一些特异性调节心脏基因的转录因子,最近又发现显性遗传转录因子的突变能引起人类先天性心脏缺陷,将心脏发育转录因子的研究直接与医学联系起来.尽管这方面的研究已经很广泛了,但心脏发育的转录调控仍不很清楚.本文对心脏转录因子及其作用研究的最新进展进行了综述.Transcription factors can regulate the expression of other genes in a tissuespecific and quantitative manner and are thus major regulators of embryonic developmental processes. Several transcription factors that regulate cardiac genes specifically have been described, and the recent discovery that dominant inherited transcription factor mutations cause congenital heart defects in humans has brought direct medical relevance to the study of cardiac transcription factors in heart development. Although this field of study is extensive, several major gaps in our knowledge of the transcriptional control of heart development still exist.Recent developments in the field of cardiac transcription factors and their roles in heart formation are reviewed.

关 键 词：转录因子 基因表达 心脏发育 先天性心脏缺陷 

分 类 号：Q756[生物学—分子生物学]