miRNA—一类新的调控微小RNA  

miRNA-A New Group of Small Temporally Regulated RNAs

作　　者：孙亚兰[1] 袁婺洲[1] 吴秀山[1] 

机构地区：[1]湖南师范大学生命科学学院蛋白质化学与发育生物学教育部重点实验室,中国湖南长沙410081

出　　处：《生命科学研究》2002年第S2期106-109,共4页Life Science Research

基　　金：国家自然科学基金资助项目(30170479);湖南省特聘教授基金资助项目(25000613);教育部重点课题项目

摘　　要：在线虫C.elegans的发育过程中,时序调节微小RNA起着很重要的作用.其中有两种关键基因lin 4和let 7长约22个核苷酸,不编码蛋白质,参与基因表达的负调节,这可能是翻译水平上的调节与发生在转录后的RNA干涉不同.研究表明它们在大小、结构和功能上具有保守性.主要从miRNA的发现、分布、形成、作用4个方面进行了综述.During the development of the nematode C.elegans, two small temporally regulated RNAs (stRNA) regulate timing of gene expression. Two of the stRNAs, lin4 and let7 are of about 22 nucleotides, nocoding protein, and are very important during the downregulation of gene expression. This regulation occurs at a posttranscriptional, presumably translational level and is distinct from RNA interference. Researches suggested that they are conserved in size, structure and function. The discovery, distributing, form and function of miRNA are mainly reviewed.

关 键 词：微小RNA 时序调节微小RNA 异时表型 

分 类 号：Q522[生物学—生物化学]