心血管疾病的研究及前景  

Studies in Cardiovascular Diseases

作　　者：刘芳[1] 朱传炳[1] 吴秀山[1] 

机构地区：[1]湖南师范大学生命科学学院蛋白质化学与发育生物学教育部重点实验室,中国湖南长沙410081

出　　处：《生命科学研究》2002年第S2期121-123,共3页Life Science Research

摘　　要：近40年来,心血管疾病药物治疗技术取得了很大的进步.人类基因组解密和基因定位技术的应用使我们进一步了解常见心血管疾病发病机制,这些成果让人们认识到心血管病理学实质上是与一系列相互关联而又相互区别的基因群联系起来的.从这个观点看来,一些关于治疗心肌症、先天性心脏病、动脉硬化症的分子发病机理和发展的资料有非常重要的意义,对已获得的多基因心血管症状包括动脉硬化和高密度脂蛋白新陈代谢的进化遗传和基因组技术的应用的局限性进行了讨论.Remarkable advances have been made in cardiovascular disease medical therapeutics and technology over the last 40 years. Elucidation of the human genome and the application of gene mapping techniques to kindreds harboring rare monogenic cardiovascular syndromes have provided fundamental insights into the pathogenesis of common cardiovascular diseases.These findings led to the unanticipated conclusion that common cardiovascular pathologies are united by associaition with distinct subsets of genes. The impact of these data on the molecular pathogenesis and development of future therapies for cardiomyopathy, congenital heart disease, and atherosclerosis are highlighted.In addition,the application and limitations of evolving genetic and genomic technologies to acquired and multigenic cardiovascular states including atherosclerosis and high density lipoprotein(HDL)metabolism are discussed. 

关 键 词：心血管疾病 基因 展望 

分 类 号：R54[医药卫生—心血管疾病]