Linkage analysis on chromosome 2 in essential hypotension pedigrees  

作　　者：XI Huifeng KE Yuehai XIAO Junhua LI Hongyu JIN Jianzhong HUANG Wei JIN Li LU Daru 

机构地区：[1]State Key Laboratory of Genetic Engineering,Center for Anthropological Studies,School of Life Sciences,Fudan University,Shanghai 200433,China [2]Chinese Human Genome Center at Shanghai,Shanghai 201203,China

出　　处：《Chinese Science Bulletin》2002年第18期1538-1540,共3页

基　　金：This work was supported by the National Key Basic Research Project (Grant No. G1998051014).

摘　　要：It is a new approach to study the important genes related to the control of blood pressure by probing into hypotension and hypertension at the same time. Genome scanning on whole chromosome 2 in 8 hypotension pedigrees has been done and parameter (LOD score) and non-parameter (NPL score) were used in the linkage analysis by GENEHUNTER software. The results show the evidence of linkage between D2S112 and D2S117, indicating a number of critical genes may lie in this region and contribute to the mechanism of blood pressure regulation. Also this region has been found in the previous study in hypertension pedigrees. These genes may play an important role in the regulation of blood pressure and can also be the important candidate genes in hypertension studies.It is a new approach to study the important genes related to the control of blood pressure by probing into hypotension and hypertension at the same time. Genome scanning on whole chromosome 2 in 8 hypotension pedigrees has been done and parameter (LOD score) and non-parameter (NPL score) were used in the linkage analysis by GENEHUNTER software. The results show the evidence of linkage between D2S112 and D2S117, indicating a number of critical genes may lie in this region and contribute to the mechanism of blood pressure regulation. Also this region has been found in the previous study in hypertension pedigrees. These genes may play an important role in the regulation of blood pressure and can also be the important candidate genes in hypertension studies.

关 键 词：HYPOTENSION GENOME scanning LINKAGE analysis GENE-HUNTER regulation of blood pressure. 

分 类 号：R544.2[医药卫生—心血管疾病]