Dynamics of RNA with A6 bulge loop  

作　　者：LIANG Chongrong & LIU CiquanKey Laboratory of Cellular & Molecular Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China Biology Department, Jinan University, Guangzhou 510630, China 

出　　处：《Chinese Science Bulletin》2002年第12期1003-1006,共4页

基　　金：This work was supported by the National Natural Science Foundation of China (Grant No. 39770418) ;the Knowledge Innovation Program of the Chinese Academy of Sciences (Grant No. KJCX1-08).

摘　　要：In order to understand the behavior of RNAs with large bulges in solution, molecular dynamics was performed on the RNA molecule in water with A6 bulge. The result of simulation showed that nonstacked conformation is the main conformation in large bulges, and the backbone of large bulge is of great conformational flexibility, but bulges-induced bends are relatively rigid. The fluctuation in bulge has little influence on the bend angle of RNAs.In order to understand the behavior of RNAs with large bulges in solution, molecular dynamics was performed on the RNA molecule in water with A6 bulge. The result of simulation showed that nonstacked conformation is the main conformation in large bulges, and the backbone of large bulge is of great conformational flexibility, but bulges-induced bends are relatively rigid. The fluctuation in bulge has little influence on the bend angle of RNAs.

关 键 词：RNA large BULGE CONFORMATION BEND angle. 

分 类 号：Q522[生物学—生物化学]