蜂针对实验性类风湿关节炎动物细胞因子影响的研究  

Effect of Bee-acupuncture on Cytpkines in Experimental Animals with Rheumatoid Arthritis

作　　者：杨顺益[1] 刘金芝[1] 冯淑兰[1] 邓金锋[1] 张宏[1] 李万瑶[1] 邝慧玲[1] 赖先娥[1] 

机构地区：[1]广州中医药大学针灸推拿学院,广州510405

出　　处：《中国病毒病杂志》2002年第1期41-43,共3页Chinese Journal of Viral Diseases

基　　金：卫生部科学研究基金(98-1-106)

摘　　要：目的 探讨蜂针对实验性类风湿关节炎(Rheumatoid Arthritis,RA)动物细胞因子的影响。方法 应用弗氏完全佐剂(Freund’s complete adjuvant,FCA)造模,观察了蜂针对实验大鼠的血清及滑膜浸液 IL-1β、IL-6的变化,以氢化可的松作为阳性对照组。结果 蜂针治疗组的大鼠血清及滑膜浸液的IL-1β、IL-6的水平较模型组明显降低(P<0.01、P<0.05)。结论 表明蜂针具有抑制佐剂性关节炎(AA)大鼠细胞因子的异常分泌的作用,以阻止AA大鼠免疫性炎症的发展。提示了蜂针对AA大鼠细胞因子的影响可能是蜂针治疗RA的免疫机制之一。Objective To investigate the effect of bee - acupuncture on cytokines in experimental animals with Rheumatoid Arthritis (RA) . Methods Freund's complete adjuvant was used to set up aminal models with RA.Eighty rats were randomly allocated to four groups: nomal control group, model group, bee - acupuncture group, hydrocortisone control group. Results After treatment for twenty-one days, the serum and synovia level of interleukin- 1β (IL- 1β) and interleukin- 6 (IL-6) . Conclusion It indicated that bee - acupuncture can regulate the level of IL - 1β and IL - 6 in rats with RA to inhibit the pathologic process of immune inflammatory.Tir may be one of the immune mechanism of RA treated by bee - acupuncure.

关 键 词：关节炎 类风湿/针灸疗法 蜂针疗法 细胞因子 动物/模型 大鼠 

分 类 号：R245[医药卫生—针灸推拿学]