Regio-and Stereo-selective Bioreduction of Diketo-n-butylphosphonate by Baker's Yeast  

作　　者：王科 李晋峰 袁承业 李祖义 

出　　处：《Chinese Journal of Chemistry》2002年第11期1379-1387,1132,共10页中国化学（英文版）

基　　金：theNationalNaturalScienceFoundationofChina (Nos.2 0 0 72 0 5 2and 2 9832 0 5 0 )

摘　　要：A regio- and stereo-selective reduction of diketo-n-butylphosphonates by baker's yeast was reported. The chemical yield and ee value of these reactions are highly dependent on the structure of substrates. The resulting optical active hydroxy^alkanephosphonates can be used as chirons for the synthesis of polyfunctional organophosphorus compounds. As useful building block, a series of α,β-unsaturated ketones bearing chiral hydroxy group in addition to trifluoromethyl moiety was prepared via the Horner-Wadsworth-Emmons (HWE) reaction of the biotransformation products.A regio- and stereo-selective reduction of diketo-n-butylphosphonates by baker's yeast was reported. The chemical yield and ee value of these reactions are highly dependent on the structure of substrates. The resulting optical active hydroxy^alkanephosphonates can be used as chirons for the synthesis of polyfunctional organophosphorus compounds. As useful building block, a series of α,β-unsaturated ketones bearing chiral hydroxy group in addition to trifluoromethyl moiety was prepared via the Horner-Wadsworth-Emmons (HWE) reaction of the biotransformation products.

关 键 词：BIOTRANSFORMATION baker's yeast diketo-n-butyl^phosphonate regio- and stereo-selective reduction 

分 类 号：O623[理学—有机化学]