Synthesis of 2-Benzylthio-5-phenyl-3,4-disubstituted Thiophenes by Intramolecular Condensation of α-Oxo Ketene Dibenzyl^thioacetals  

作　　者：王芒 艾林 张继余 刘群 高连勋 

出　　处：《Chinese Journal of Chemistry》2002年第12期1591-1597,1464,共0页中国化学（英文版）

基　　金：theNationalNaturalScienceFoundationofChina (No. 2 986 2 0 0 4),theScienceandTechnologyDevelopmentProgramFoundationofJilinProvince (No.2 0 0 10 5 0 5)andtheYouthFoundationofNortheastNormalUniversity (No.111379)

摘　　要：A facile route to 2-benzylthio-5-phenyl-3,4-disubstituted thiophenes was described. Catalyzed by sodium hydroxide, the title compounds were synthesized in moderate to good yields simply from the intramolecular aldol type condensation of α-oxo ketene dibenzylthioacetals. The chemical selectivity for this annulation reaction was studied and discussed.A facile route to 2-benzylthio-5-phenyl-3,4-disubstituted thiophenes was described. Catalyzed by sodium hydroxide, the title compounds were synthesized in moderate to good yields simply from the intramolecular aldol type condensation of α-oxo ketene dibenzylthioacetals. The chemical selectivity for this annulation reaction was studied and discussed.

关 键 词：α-oxo ketene dithioacetals α-oxo ketene dibenzylthioacetals multisubstituted thiophenes intramolecular aldol type condensation 

分 类 号：O626[理学—有机化学]