纯阳子对兔髂动脉球囊成形术后血管重塑影响的实验研究  

Effect of Pyraceantha fortuneana on Vascular Remodeling after Balloon Angioplasty in lliac Artery of Rabbits

作　　者：肖敏[1] 张群林[2] 黄从新[1] 郭青平[2] 刘峰松[2] 

机构地区：[1]武汉大学亚太医院,武汉430060 [2]湖北十堰郧阳医学院附属太和医院

出　　处：《中国中西医结合杂志》2001年第S1期8-10,共3页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：目的:探讨抗氧化剂纯阳子对球囊损伤后血管重塑的影响。方法:32只日本大耳白兔分成4组。A 组(n=8):左侧髂动脉为假手术组,右侧为正常对照组。B 组(n=8):双侧髂动脉球囊成形术组。C组(n=8):双侧髂动脉球囊成形术加维生素 C、维生素 E 组。D 组(n=8):双侧髂动脉球囊成形术加纯阳子组。术前7天开始用药,一直持续到术后28天处死动物。用计量组织学方法观察不同时间点及不同组别的血管内膜面积、中膜面积、腔面积、内弹力板所包围的面积及外弹力板所包围面积的变化。测定不同时间点、不同组别的血清 LPO 和 SOD 的变化。结果:(1)与 B 组比较,C 组和 D 组的各项形态学指标有明显差异(P&0.05);血中 LPO 及 SOD 亦有差异。(2)各处理组间内膜面积差异无显著性。(3)IA/VA(血管对创伤反应指数)在各处理组间差异有显著性(P<0.05)。结论:通过改善氧化还原状态,纯阳子对血管重塑可产生有益影响,从而达到降低再狭窄的目的。Objective:To investigate the effect of Pyraceantha fortuneana (PF),an antioxidant,on vascular remodeling after balloon angio- plasty.Methods:Thirty-two rabbits were divided into 4 groups,8 in each group.The fight lilac artery in Group A was taken as control and the left one was sham-operated.Bilateral balloon angioplasty was carried out on both sides' lilac arteries in Group B.Bilateral balloon angioplasty with vitamin C+ vitamin E was done in Group C.Bilateral balloon angioplasty+PF was carried out in Group D.The treat- ments were started from 7 days before operation and lasted till 28 days after operation,the time of sacrificing.The changes on areas of vascular intima,tunica media,cavitary,inner and outer elastic plate encircled area in different time points and groups were estimated with histomorphometric method.Moreover,the changes of serum level of lipid peroxidase (LPO) and superoxide dismutase (SOD) in the corresponding time points and groups were determined as well.Results:Significant difference was shown in comparing various mor- phologic parameters as well as levels of SOD and LPO in Group C and D with those in Group B (P<0.05).The difference of vascular intimal area in all treated groups were insignificant,while that of the IA/VA (response index of blood vessel to injury) among treated groups were significant (P<0.05).Conclusion:By improving the oxidation-reduction manner,PF produce a beneficial effect on vascular remodeling so as to reduce the occurrence of restenosis.

关 键 词：纯阳子 抗氧化剂 球囊成形术 血管重塑 

分 类 号：R285.5[医药卫生—中药学]