生脉注射液对大鼠肥厚心肌肌浆网钙泵功能及钙超载的影响  

Effects of Shengmai Injection on Sarcoplasmic Reticular Ca^(2+)-ATPase and Calcium Overload of Hypertropic Myocardium in Rats

作　　者：陈捷[1] 张亚臣[1] 吕宝经[1] 荣烨之[1] 赵美华[1] 黄国芳[1] 

机构地区：[1]上海第二医科大学附属新华医院心内科,上海200092

出　　处：《中国中西医结合杂志》2001年第S1期13-14,共2页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：上海市教委青年基金资助(No.97QB36)

摘　　要：目的:研究生脉注射液对大鼠慢性压力超负荷引起心肌肌浆网钙泵功能紊乱及心肌钙超栽的影响。方法:以腹主动脉狭窄大鼠为模型,测定术后12周大鼠的血压、心肌重量、钙含量、肌浆网 CA^(2+)-ATP酶摄钙功能和水解活性。结果:与模型组比较,生脉注射液组大鼠心肌钙泵功能稳定,心肌钙含量无明显增高,心肌肥厚减轻。结论:生脉注射液对慢性压力超负荷引起心肌肌浆网钙泵功能紊乱及钙超载有较好的防治作用,可延缓心肌肥厚向心衰转化的进程。Objective:To study the effects of Shengmai Injection (SM) on sarcoplasrnic reticular Ca^(2+)-ATPase (SERCA) disorder and calci- um overload induced by chronic pressure overburden.Methods:12 weeks after abdominal aorta constriction models were established, rats' blood pressure,heart weight,myocardial calcium content,function of SERCA and activity of hydrolysation were determined.Re- sults:In comparing with model group,the functions of SERCA were stable in rats treated by SM,the myocardial calcium content was not increased,and myocardial hypertrophy alleviated.Conclusion:SM could efficiently prevent and treat SERCA disorder,calcium over- load induced by chronic pressure overburden,and could retard the progressive process from myocardial hypertrophy to heart failure.

关 键 词：生脉注射液 心肌肥厚 钙超载 Ca²⁺-ATP 酶 

分 类 号：R285.5[医药卫生—中药学]