调理脾胃复方对癫痫大鼠脑内环核苷酸含量的影响  

Effect of Spleen-Stomach Regulating Prescription on Cyclic Nucleotides Content in the Brain of Rats with Epilepsy

作　　者：张丽萍[1] 王洪图 白丽敏[2] 贺娟[2] 

机构地区：[1]广西中医学院,南宁530001 [2]北京中医药大学,北京100029

出　　处：《中国中西医结合杂志》2001年第S1期50-51,共2页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：目的:观察调理脾胃复方对癫痫大鼠脑内环核苷酸(CN)含量的影响。方法:腹腔注射戊四唑建立大鼠癫痫模型,观察调理脾胃复方对大鼠脑内 CN 含量的影响及其抗痫效应。结果:调理脾胃复方对大鼠脑内 CN 水平有调节作用,并能明显降低惊厥级别,减轻癫痫发作程度。结论:调理脾胃复方对癫痫大鼠的拮抗作用可能与其调节脑内 CN 含量有关。Objective:To study the effect of Spleen-Stomach Regulating Prescription (SSRP) on cyclic nucleotides (CN) content in the brain of rats suffered from epilepsy.Methods:Rat model of mimetic epilepsy was established by injection of pentylentetrazol (PTZ).The anti- epileptic effect and effect of SSRP on CN Level in brain were observed using radioimuunoassay (RIA).Results:SSRP could regulate the CN level and effectively lower the grade of convulsion and alleviate the degree of epileptic attack.Conclusion:Possibly the anti- epileptic effect of SSRP was correlated with the content of CN in brain.

关 键 词：调理脾胃复方 癫痫 环核苷酸 戊四唑 大鼠 

分 类 号：R285.5[医药卫生—中药学]