Cytochalasin B loaded nano/microparticles:preparation and in vitro drug release evaluation  

作　　者：SONG Cun xian SUN Hong fan YANG Jin ZHU Zhen feng WANG Peng yan Robert Levy 

机构地区：[1]Institute of Biomedical Engineering,Peking Union Medical College,Chinese Academy of Medical Sciences,Tianjin 300192,China

出　　处：《Chinese Journal of Biomedical Engineering(English Edition)》2000年第1期1-9,共9页中国生物医学工程学报（英文版）

摘　　要：Cytochalasin B (cytoB) loaded nanoparticles (NPs) and microspheres (MSs) were formed using an emulsification / solvent evaporation technique.Biodegradable poly(lactic co glycolic acid)(PLGA) and poly(L lactic acid)(PLLA)were used as carrier and were compared in terms of drug release rate and initial burst.The PLGA nanoparticles and microparticles of graded diameter,150 nm,500 nm,1 μm,5 μm,10 μm and 20 μm,is formulated.Nanoparticles of 150 500 nm diameter were obtained by high energy sonication,whereas larger size particles were obtained by normal homogenization.The degree of initial burst release varied depending on particle size and polymer matrix.For the PLGA matrix,about 50% of the entrapped drug released from the 150 nm nanoparticles,whereas only 10% released from the 20 μm particles within the first 24 hours.On the other hand,cytoB release from 150 nm PLLA nanoparticles was much slower and showed less burst effect than the PLGA ones with same size.The results suggest that desired release profile can be achieved by properly selecting the matrix material and particle size.Cytochalasin B (cytoB) loaded nanoparticles (NPs) and microspheres (MSs) were formed using an emulsification / solvent evaporation technique.Biodegradable poly(lactic co glycolic acid)(PLGA) and poly(L lactic acid)(PLLA)were used as carrier and were compared in terms of drug release rate and initial burst.The PLGA nanoparticles and microparticles of graded diameter,150 nm,500 nm,1 μm,5 μm,10 μm and 20 μm,is formulated.Nanoparticles of 150 500 nm diameter were obtained by high energy sonication,whereas larger size particles were obtained by normal homogenization.The degree of initial burst release varied depending on particle size and polymer matrix.For the PLGA matrix,about 50% of the entrapped drug released from the 150 nm nanoparticles,whereas only 10% released from the 20 μm particles within the first 24 hours.On the other hand,cytoB release from 150 nm PLLA nanoparticles was much slower and showed less burst effect than the PLGA ones with same size.The results suggest that desired release profile can be achieved by properly selecting the matrix material and particle size.

关 键 词：CYTOCHALASIN B NANOPARTICLE MICROSPHERE 

分 类 号：R319[医药卫生—基础医学]