Studies on the Voltammetric Behavior of Nicardipine Hydrochloride and its Voltammetric Determination at the Co/GC Modified Electrode  

作　　者：ZHI Yao HU Jingbo LI Qilong HUANG Qingquan 

机构地区：[1]Department of Chemistry,Beijing Normal University,Beijing,100875 [2]National Institute for the Control of Pharmaceutical and Biological Products,Beijing,100050

出　　处：《Chemical Research in Chinese Universities》1999年第2期36-41,共6页高等学校化学研究(英文版)

摘　　要：ＩｎｔｒｏｄｕｃｔｉｏｎＴｈｅｔｅｃｈｎｉｑｕｅｏｆｉｏｎｉｍｐｌａｎｔａｔｉｏｎｈａｓｂｅｅｎｄｅｖｅｌｏｐｅｄａｓａｍｅａｎｓｏｆｉｎｔｒｏｄｕｃｔｉｎｇｆｏｒｅｉｇｎａｔｏｍｓｉｎｔｏｔｈｅｓｕｒｆａｃｅｌａｙｅｒｓｏｆａｓｏｌｉｄ．Ｔｈｉｓｔ...In a 002 mol/L BR buffer solution(pH=552),the electrochemical behaviour of nicardipine hydrochloride was studied by linearsweep voltammetry and cyclic voltammetry at a Co/GC ion implantation modified electrode.The experiments showed that the electrode had a good stability and reproductivity.The peak height was proportional to the concentration of nicardipine over the range of 4010-71010-4 mol/L and the detection limit was 1010-7 mol/L.This method has been used for the direct determination of nicardipine in tablets.Its recoveries were in the range from 956%to 1038%.The reduction of nicardipine at the Co/GC electrode was an irreversible proccess.

关 键 词：Ion implantation Modified electrode NICARDIPINE Linearsweep voltammetry 

分 类 号：TN305.3[电子电信—物理电子学] O646.5[理学—物理化学]