双歧杆菌对小鼠体液免疫功能的影响  

INFLUENCE OF BIFIDOBACTERIUM ON MURINE HUMORAL IMMUNE FUNCTION

作　　者：梁庆红[1] 王倩[1] 张琳[1] 张亚超[2] 王沛[2] 周志广[3] 

机构地区：[1]河北医科大学第三医院,河北石家庄050000 [2]中国人民解放军白求恩军医学院 [3]河北迁安市人民医院

出　　处：《承德医学院学报》2004年第2期100-101,共2页Journal of Chengde Medical University

摘　　要：目的 :探讨双歧杆菌减少对小鼠体液免疫功能的影响。方法 :抗生素脱污染造成肠道双歧杆菌数量减少 ,溶血空斑实验测定抗体生成细胞的数量并测量的重量。结果 :实验组小鼠肠道内双歧杆菌数量明显低于对照组 (P<0 .0 1 ) ;脾细胞悬液的溶血空斑细胞数量及脾脏的重量均较对照组明显减少 (P<0 .0 1 ) ;双歧杆菌数量与溶血空斑细胞数和脾脏重量呈显著正相关。结论 :双歧杆菌减少可降低机体体液免疫功能 。Objective:To explore the influence of Bifidobacterium on murine humoral immune function.Methods:Bifidobacterium is decreased by antibiotics.Results:1.In the test group,the number of Bifidobacterium is obviously smaller than that in contrast group (P<0.01).2.The number of PFC cell,the weight of the spleen in the test group have obviously decreased when compared with that in the control group (P<0.01).3.Analysis of the correlations shows that there are marked positive correlations between Bifidobacteria and each immune index.Conclusion:The results suggest that the smaller number of Bifidobacteria may decrease the humoral immune function.

关 键 词：双歧杆菌 体液免疫功能 菌群失调 

分 类 号：R378.2[医药卫生—病原生物学]