梗阻性黄疸患者抗内毒素治疗的临床研究  

CLINICAL STUDY OF ANTI - ENDOTOXIN THERAPY ON PATIENTS WITH OBSTRUCTIVE JAUNDICE

作　　者：刘大平[1] 李梅[1] 张利[1] 李智华[2] 何振平[2] 

机构地区：[1]成都军区昆明总医院曲靖分院外科,云南曲靖655000 [2]重庆第三军医大学西南医院肝胆外科,重庆400038

出　　处：《西南国防医药》1999年第3期135-137,共3页Medical Journal of National Defending Forces in Southwest China

摘　　要：收集36例梗阻性黄疸病人,随机分3组。分别按常规手术治疗、术前加服胆酸钠及术前静脉注射拮抗内毒素抗体处理,并与20例正常人群作对照。于用药前、术前、术后观察血浆内毒素、血尿素及肌酐含量变化。结果:术前应用拮抗内毒素抗体或口服胆盐治疗可明显降低血中内毒素水平、改善肾功能,治疗前后有非常显著变化(P<0.01)。组间比较加用药物治疗组与常规手术组之间有显著差异(P<0.01)。提示术前应用抗内毒素药物可有效降低术后血中内毒素含量,减少术后肾功能衰竭和死亡率的发生。36 patients with obstructive jaundice were observed in this study. They were divided into three groups. In OJT1 group, the patients had been treated with oral bile salt for five to seven days before operation; in OJT2 group, anti -endotoxin antibody had been injected venously for three days before operation; only operation was performed in OJ group. Another 20 normal persons were used as the control group. The level of endotoxin, urea and creatinine in these subjects' blood were detected before the administrating drugs, before and after operation. The results indicated that the levels of endotoxin, urea and creatinine in the blood of OJT1 and OJT2 group decreased dramatically after the anti-endotoxin treatment (P<0. 01). It was suggested that the post-opeartional syndrome improved and the mortality of obstructive jaundice decreased.

关 键 词：梗阻性黄疸 内毒素 肾功能 抗内毒素治疗 

分 类 号：R657.3[医药卫生—外科学]