动脉粥样硬化症与肺炎衣原体感染——91例尸检结果报告  

Atherosclerosis and infection of chlamydia pneumoniae 91 cases autopsy report

作　　者：冯根宝[1] 鲁刚[1] 朱清於[1] 詹化文[1] 胡兰萍[1] 施毅[1] 

机构地区：[1]南京军区南京总医院内科实验室

出　　处：《医学研究生学报》1999年第2期36-39,共4页Journal of Medical Postgraduates

摘　　要：目的：调查国内动脉粥样硬化症患者肺炎衣原体感染的状况。方法：尸检取主动脉粥样硬化病灶与非硬化病灶组织，应用套式ＰＣＲ技术检测血管组织中的肺炎衣原体特异性基因扩增产物。结果：病理证实伴动脉粥样硬化症的８８例尸检主动脉组织中，３４例检出肺炎衣原特异性基因扩增产物，阳性率达３８．６％；ＤＮＡ序列分析表明，基因扩增产物与肺炎衣原体标准菌株基因序列完全一致。结论：我国动脉粥样硬化症患者主动脉血管组织中存在肺炎衣原体感染，感染率与国外报道相近，其临床意义有待深入探讨。Objectives: To evaluate the incidence of chlamydia pneumoniae infection in domestic atherosclerosis. Methods: The technique of nested polymerase chain reaction for detect specific DNA of chlamydia pneumoniae. Results: 34 of 88 autopsy with atherosclerosis were positive(38.6%). The specificity of the PCR amplified product was confirmed by DNA sequence analysis technique. Conclusions: Our study reveals that the infection rate of chlamydia pneumoniae is up to 40% at least in the patients with atherosclersis and the results are similar with abroad reports,but the significance and relationship between infection of chlamydia pneumoniae and atherosclerosis waited for further research.

关 键 词：动脉粥样硬化 肺炎衣原体 套式聚合酶链反应 DNA基因扩增技术 

分 类 号：R541.4[医药卫生—心血管疾病]