Clinical and Experimental Study on Treatment of Fatty Liver of Phlegm-Dampness Stagnation Type by Zhiganle (脂肝乐) Capsule  

作　　者：赵文霞 段荣章 苗明三 冀爱英 蒋时红 陈天朝 张照兰 

出　　处：《Chinese Journal of Integrative Medicine》1999年第1期25-28,共4页中国结合医学杂志（英文版）

摘　　要：Objective: To explore the mechanism of Zhiganle capsule (脂肝乐, ZGLC) in treating fattyliver of Phlegm-Dampness Stagnation type. Methods: One hundred and forty-six patients were treated withZGLC, the effects were observed and compared with those treated with Dongbao Gantai (DBGT, 东宝肝泰)tablets as control. The effect of ZGLC on ethionine induced hyperlipemia model rats was also observed. Results:The effect of ZGLC was obviously better than those of DBGT in relieving or removing symptoms, normalizingthe ultrasonic abnormal findings, lowering the serum levels of lipid and enzyme and improving hemorrheologicfunctions. Experimental study showed that ZGLC could reduce the blood lipids, inhibit the lipid deposition inliver. As compared with the model group, level of triglyceride in the ZGLC treatment group were much lowered(P < 0. of ) and the effect was better than those in the control group. Conclusions: ZGLC has the effect of reducing blood triglyceride level, inhibiting lipid deposition in liver and improving hemorrheologic function.Keywods: Zhiganle capsule; Phlegm--Dampness Stagnation; animal model of fatty liverObjective: To explore the mechanism of Zhiganle capsule (脂肝乐, ZGLC) in treating fattyliver of Phlegm-Dampness Stagnation type. Methods: One hundred and forty-six patients were treated withZGLC, the effects were observed and compared with those treated with Dongbao Gantai (DBGT, 东宝肝泰)tablets as control. The effect of ZGLC on ethionine induced hyperlipemia model rats was also observed. Results:The effect of ZGLC was obviously better than those of DBGT in relieving or removing symptoms, normalizingthe ultrasonic abnormal findings, lowering the serum levels of lipid and enzyme and improving hemorrheologicfunctions. Experimental study showed that ZGLC could reduce the blood lipids, inhibit the lipid deposition inliver. As compared with the model group, level of triglyceride in the ZGLC treatment group were much lowered(P < 0. of ) and the effect was better than those in the control group. Conclusions: ZGLC has the effect of reducing blood triglyceride level, inhibiting lipid deposition in liver and improving hemorrheologic function.Keywods: Zhiganle capsule; Phlegm--Dampness Stagnation; animal model of fatty liver

关 键 词：Zhiganle capsule Phlegm-Dampness Stagnation animal model of fatty liver 

分 类 号：R259.75[医药卫生—中西医结合]