2型糖尿病患者GMP-140,PC,Fbg和D-D含量检测的临床意义  

Clinical Significance of Detecting GMP - 140, Protein C, Fibrinogen and D - dimmer in patients with Non - Insulin Dependent Diabetes Mellitus (NIDDM)

作　　者：张新华[1] 江强 李爱群[1] 何世安[1] 朱凌[1] 周天红[1] 

机构地区：[1]解放军303医院血液科,南宁530021 [2]武警广西边防总队门诊部,南宁530031

出　　处：《血栓与止血学》1999年第4期160-162,共3页Chinese Journal of Thrombosis and Hemostasis

摘　　要：目的:探讨2型糖尿病患者检测血小板α-颗粒膜蛋白(GMP-140)。蛋白C(PC),纤维蛋白原(Fbg)和 D二聚体(D-D)含量的临床意义。方法:用 ELISA法和免疫比浊法分别检测,GMP-140、PC、Fbg和D-D含量结果:2型糖尿病患者GMP-140、Fbg和D-D含量明显高于健康年轻人组,而PC明显低于健康年轻人组,与脑梗死患者相同除D-D外,GMP-140、PC和Fbg与健康老年人组比较无显著性差异。结论:糖尿病的治疗应在控制血糖的同时结予抗凝和改善血液循环的治疗,以预防血栓形成。Objective: To detect plasma level of GMP- 140, Protein C (P. C.), Fibrinogen (Fbg) and D -dimmer(D-D) and discuss its clinical significance. Methods: CMP-140, P.C., Fbg and D - D were detection respecticely with ELISA or ininiuturbidinietry. Results:The level of GMP- 140, Fbg and D - D in diabetic patients higher than those of healthy young adults, tasides PC. The levels of GMP- 140, PC. and Fbg were increased between diabetic patients and old healthy adults. There was not significant between them. Conclusion; The treatment of anti - coagulating is very important tn diebetic patients. It can prevent the patients from thrombosis.

关 键 词：2型糖尿病 血小板颗粒膜蛋白 蛋白C 纤维蛋白原 D二聚体 

分 类 号：R587.1[医药卫生—内分泌]