硝酸甘油贴膜防治激素性股骨头坏死的实验研究  

Experimental Study on Nitroglycerin Adhesive Patch to Prevent Femoral Head Necrosis Caused by Corticosteroids

作　　者：张卫平[1] 步建立[1] 刘长安[1] 周吉怀[1] 陈百成[2] 成继民[1] 马毓梅[1] 张文[1] 

机构地区：[1]白求恩和平医院,石家庄050082 [2]河北医科大学附属三院,石家庄050081

出　　处：《解放军医药杂志》1999年第4期257-259,322,共4页Medical & Pharmaceutical Journal of Chinese People’s Liberation Army

摘　　要：目的 研究一氧化氮供体硝酸甘油防治激素性股骨头坏死的作用。方法 A组给新西兰白兔注射大剂量甲基强的松龙,然后在腹部贴硝酸甘油贴膜;B组单纯注射大剂量甲基强的松龙;C组生理盐水对照,观察指标:实验前、实验1、2、3、4周抽静脉血测定NO、NOS、甘油三脂和胆固醇水平。4周后处死动物,取股骨头作病理检查。结果 病理检查:A组1/7发生股骨头坏死;B组4/7发生股骨头坏死;C组无。血清学检查:三组间NO、甘油三脂和胆固醇方差分析结果P<0.001。B组NO水平下降显著,甘油三脂和胆固醇上升明显。A组应用硝酸甘油贴膜后NO水平稍升高。结论 硝酸甘油贴膜通过释放NO,预防激素性股骨头坏死。Objective To study effect of nitroglycerin adhesive patch prevent femoral head necrosis carsed by coricalsteroids. Methods A group were injected once 20mg/kg of body weight of methylprednisolone and sticked on nitroglycerin adhesive patch on abdomen, B group were injected once the same dose of methylprednisolone, C group were injected once with physiologic saline as control. The plasma levels of NO、NOS、triglycerides,cholesterol were examinate before injection and 1、2、3、4 week after injection. After injected 4 weeks, the rabbits were killed and observed the histopatholo-gical changes of the femoral head. Results Histopathoogical change: 1/7 rabbits occurred necrosis of femoral head in A group, so 4/7 rabbits did in B group and none in C group. Hematologic examination: The P value in analysis of variance of NO、triglycerides、 cholesterol were less than 0. 001. The level of NO decreased remarkable, but that of triglycerides and cholesterol went up significantly in B group. The level of NO went ups dlightly in A group after treated by nitroglycerin adhesive patch. Conclusion Nitroglycerin adhesive patch release Nitric Oxide to prevent femoral head necrosis caused by corticalsteroids.

关 键 词：一氧化氮 硝酸甘油 股骨头坏死 皮质激素 

分 类 号：R681.8[医药卫生—骨科学]