米非司酮对大白鼠子宫内膜抗着床作用的组织化学观察  

HISTOCHEMICAL OBSERVATION ON ANTI IMPLANTATION EFFECT OF MIFEPRISTONE ON THE RATS ENDOMETRIUM

作　　者：董大翠[1] 吴熙瑞[1] 程绍瑜 张艳[1] 刘云华[1] 

机构地区：[1]同济医科大学基础医学院

出　　处：《中国组织化学与细胞化学杂志》1998年第4期73-76,共4页Chinese Journal of Histochemistry and Cytochemistry

摘　　要：３０只雌性ＳＤ大鼠分为五组，即Ａ组（阴性对照组），Ｂ组（孕三烯酮阳性对照组１ｍｇ／ｋｇ），Ｃ组（米非司酮实验组，Ｃｌ１２ｍｇ／ｋｇ，Ｃ２６ｍｇ／ｋｇ，Ｃ３３ｍｇ／ｋｇ）。用组织化学方法观察米非司酮对子宫内膜一氧化氮合成酶（ＮＯＳ）、琥珀酸脱氢酶（ＳＤＨ）、乳酸脱氢酶（ＬＤＨ）、酸性磷酸酶（ＡＣＰ）、硷性磷酸酶（ＡＬＰ）活性和糖原含量的影响。实验结果显示：ＮＯＳ，ＳＤＨ和ＡＬＰ活性较阴性对照组弱，ＬＤＨ和ＡＣＰ活性较阴性对照组强，糖原含量略低于阴性对照组。30 SD female rats were divided into five groups. Group A was normal control, Group B was given gestrinone, and group C was fed with a solution containing mifepristone. The dosage for groupC was 12mg(C 1), 6mg(C 2) or 3mg/kg(C 3) respectively. Histochemical methods were used to show NOS, SDH, LDH, ACP, ALP and glycogen in the endometrium of the rats. The results showed that the activity of NOS, SDH and ALP decreased in groups treated with mifepristone, but the activity of LDH and ACP was increased, and glycogen became lower than normal control

关 键 词：米非司酮 抗着床 酶组织化学 子宫内膜 大鼠 

分 类 号：R979.22[医药卫生—药品]