实验性运动病大鼠神经细胞钙离子超微结构定位变化  

CHANGES OF ULTRASTRUCTURAL LOCALIZATION OF CALCIUM IONS IN RAT BRAIN DURING EXPERIMENTAL MOTION SICKNESS

作　　者：徐根兴 王琰[1,2] 董文度 袁驾南[1,2] 金淑仪 庄坚 姜正林[1,2] 李建成 

机构地区：[1]海军神经生物学研究中心细胞生物学研究室 [2]南通医学院航海医学研究所

出　　处：《中国组织化学与细胞化学杂志》1998年第4期99-103,共5页Chinese Journal of Histochemistry and Cytochemistry

基　　金：海军科研基金

摘　　要：本研究采用正负交变加速度旋转刺激法制备大鼠运动病模型，并用钙离子（Ｃａ２＋）超微结构定位法观察了运动病大鼠大脑皮质、小脑皮质和脑干前庭区神经细胞中的Ｃａ２＋变化。结果表明，运动病大鼠大脑皮质、小脑皮质和脑干前庭区神经细胞胞质基质、线粒体和内质网中Ｃａ２＋反应产物增多。提示运动病的发生与中枢神经细胞Ｃａ２＋内流有关。In this research the model of rat motion sickness was developed by rotatory stimulation with alternative positive and negative acceleration. The changes of ultrastructural localization of calcium ions (Ca 2+ ) in rat brain were observed under EM. The results showed that the reaction products of Ca 2+ in cytoplasmic matrix, mitochondria and endoplasmic reticulum in neurons of cerebral cortex, cerebellar cortex and vestibular area of brain stem of rats with motion sickness were increased. This implies that the development of motion sickness is closely related to Ca 2+ inflow of nerve cells in central nervous system.

关 键 词：实验性运动病 钙离子 前庭刺激 超微结构 大鼠 

分 类 号：Q26[生物学—细胞生物学]