Application of charge transfer reaction in the pharmaceutical analysis——Determination of chlorhexidine acetate  

作　　者：李华侃 赵凤林 童沈阳 

机构地区：[1]Department of Chemistry, Peking University, Beijing 100871, China

出　　处：《Chinese Journal of Chemistry》1999年第2期150-154,共5页中国化学（英文版）

基　　金：Project (No. 29392601) supposal by the National Natural Science Foundation of China

摘　　要：A spectrophotometric method for the determination of chlorhexidine acetate is described. The reaction between chlorhexidine acetate and chloranil took place in an alcohol-acetone solution at room temperature. The composition of the charge transfer complex is 1:2. Beer's law is obeyed in the concentration range of 15–270 μg·mL?1 with correlation coefficient 0.9995. The apparent molar absorptivity is 2.21 × 103 L·mol?1·cm?1 at 412 nm. The method is accurate (with a recovery af 100 ± 1.6% ) and precise (RSD =1.0%). It was successfully applied to determine chlorhexidine acetate in suppository or disinfectant solution.A spectrophotometric method for the determination of chlorhexidine acetate is described. The reaction between chlorhexidine acetate and chloranil took place in an alcohol-acetone solution at room temperature. The composition of the charge transfer complex is 1:2. Beer's law is obeyed in the concentration range of 15–270 μg·mL?1 with correlation coefficient 0.9995. The apparent molar absorptivity is 2.21 × 103 L·mol?1·cm?1 at 412 nm. The method is accurate (with a recovery af 100 ± 1.6% ) and precise (RSD =1.0%). It was successfully applied to determine chlorhexidine acetate in suppository or disinfectant solution.

关 键 词：Chlorhexidine acetate CHLORANIL charge transfer reaction SPECTROPHOTOMETRY 

分 类 号：TQ460[化学工程—制药化工]