A highly enantioselective synthesis of 5- (ι-menthyloxy) -4-substituted-3-chloro-2(5H) -furanones  

作　　者：耿哲 黄彬 陈庆华 

机构地区：[1]Department of Chemistry, Beijing Normal University, Beijing 100875, China Current address: Department of Chemistry, Capital Normal University, Beijing 100037, China.

出　　处：《Chinese Journal of Chemistry》1999年第2期189-195,共7页中国化学（英文版）

基　　金：Project (No. 29132036) supported by the National Natural Science Foundation of China

摘　　要： In this paper, stereocontrolled tandem Michael addition-elimination reaction of the novel chiral source, S-(ι-menthyloxy)-3,4-dichloro-2(5H)-furanone, with various thiols and amines has been investigated. A series of new enantiomerically pure compounds, 5-(ι-menthyloxy)-4-substituted-3-cnloro-2(5H)-furanones, were obtained in good yields with d. e.(?)98% under mild conditions.In this paper, stereocontrolled tandem Michael addition-elimination reaction of the novel chiral source, S-(ι-menthyloxy)-3,4-dichloro-2(5H)-furanone, with various thiols and amines has been investigated. A series of new enantiomerically pure compounds, 5-(ι-menthyloxy)-4-substituted-3-cnloro-2(5H)-furanones, were obtained in good yields with d. e.(?)98% under mild conditions.

关 键 词：Tandem Michael addition-elimination reaction 5-(ι-menthyloxy)-3 4-dichloro-2 (5H)-furanone enantiomerically pure compound 5-(ι-menthyloxy)-4-substituted-3-chloro-2(5H)-furanone 

分 类 号：O621[理学—有机化学]