人工髓核材料(半晶聚乙烯醇水凝胶弹性体)的研制  

Development of Artificial Disc Nucleus Materials (Semicrystalline Polyvinyl Alcohol Hydrogel Elastomers)

作　　者：顾正秋[1] 马远征[2] 高瑾[1] 刘建涛[1] 李永[1] 

机构地区：[1]北京科技大学材料科学与工程学院,北京100083 [2]解放军309医院骨科,北京100091

出　　处：《生物医学工程学杂志》2004年第3期347-349,共3页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目 ( 5 9775 0 3 8)

摘　　要：研制一种可替代椎间盘髓核并恢复其功能的生物医用材料 ,探讨半晶聚乙烯醇水凝胶弹性体材料临床应用的可行性。聚乙烯醇 (PVA)水溶液在 - 2 0℃下冷冻 6～ 12 h,室温下融化 1～ 2 h,上述过程重复 1～ 3次 ,然后对试样进行真空脱水 ,制得人工髓核材料 (半晶 PVA水凝胶弹性体 )。差示扫描量热法 (DSC)和力学性能试验研究了 PVA水溶液浓度、真空脱水和 γ射线辐照对水凝胶For the purpose of developing of disc nucleus replacement (semicrystalline PVA hydrogel elastomers) and explorating the possibility of clinical application, in this study,the aqueous PVA solution froze at -20℃ for 6-12 h, and then thawed at room temperature for 1-2h. The same process was repeated 1-3 times. After the specimen was dehydrated in vacuum, a kind of artificial disc nucleus materials (semicrystalline PVA hydrogel elastomers ) was formed. DSC and mechanical tests were conducted to investigate the influence of aqueous PVA solution concentration, of dehydrating in vacuum, and of γ-ray irradiating upon the degree of crystallity and mechanical properties of PVA hydrogel elastomers.

关 键 词：人工髓核材料 半晶聚乙烯醇水凝胶弹性体 生物医用材料 力学性能 结晶度 椎间盘 

分 类 号：R318.08[医药卫生—生物医学工程]