血清甲状腺激素水平与老年COPD患者病情变化的关系  

Relationship between thyroxin level in serum and severity of aged patients with COPD

作　　者：周伊南[1] 盛华[1] 符礼刚[1] 陈惟隽[1] 魏良[1] 朱惠莉[1] 

机构地区：[1]华东医院呼吸内科,上海200040

出　　处：《中国老年学杂志》2004年第6期493-495,共3页Chinese Journal of Gerontology

摘　　要：目的　探讨血清甲状腺激素水平与老年 COPD患者病情变化的关系。方法　用放射免疫法分别测定 35例健康者 (对照组 )和 2 69例COPD患者 (包括缓解期和急性加重期 )血清 TT3、TT4 、FT3、FT4 和 TSH水平并对数据进行统计学分析。结果　 COPD缓解期患者血清甲状腺激素水平与对照组相比差异无显著意义 ,而急性加重期患者甲状腺激素水平明显降低 (P<0 .0 5)。急性加重期无肺心病及呼衰组、有肺心病但无呼衰组和呼衰组患者的 FT3和 TT4 差异有显著性 (P<0 .0 5) ,其中以呼衰组患者最低。另外 ,FT3水平下降与 Pa O2 下降成正相关 ,而且 COPD死亡组患者TT3、TT4 、FT3和 FT4 水平均明显低于存活组 (P<0 .0 5) ,但 TSH值无明显差异。结论　 COPD急性加重患者存在着血清甲状腺激素水平的异常 ,其甲状腺激素水平与 COPD的严重性。Objective To investigate the relationship between thyroxin level in serum and clinical condition of aged patients with COPD Methods The levels of TT 3, TT 4, FT 3, FT 4 and TSH were tested in 269 patients with COPD (include stable period and exacerbation period) and 35 healthy controls by radioimmunoassay, and the data were analyzed statistically by SPSS Results There was no significant difference of thyroxin level between the patients with COPD in stable period and the controls But the levels of thyroxin in patients with COPD of acute exacerbation period were significantly lower ( P <0 05) In the three acute exacerbation groups, the levels of FT 3 and TT 4 were different among the cases without corpulmonale and respiratory failure, the cases with corpulmonale but no respiratory failure and the cases with respiratory failure ( P <0 05), especially lowest in the respiratory group On the other side, the descent of PaO 2 and FT 3 level was positive correlation The levels of TT 3, TT 4, FT 3, FT 4 in died patients with COPD were lower than those of survival group ( P <0 05), but there was no significance difference in TSH (P≈0 05) Conclusions The thyroxin levels in serum of aged patients with COPD in acute exacerbation period are abnormal and related with the severity, progress and prognosis of COPD

关 键 词：COPD 甲状腺激素 相互关系 

分 类 号：R563[医药卫生—呼吸系统]