单纯疱疹病毒性脑炎的脑电图、P_(300)和临床  

CLINICAL FEATURES AND CHANGES OF EEG AND P_(300) IN PATIENTS WITH HERPES SIMPLEX ENCEPHALITIS

作　　者：郭斌[1] 王爱芹[1] 郭丽华[1] 迟兆福[1] 王淑贞[1] 

机构地区：[1]山东医科大学附属医院神经内科,250012

出　　处：《现代电生理学杂志》1998年第2期57-59,共3页Journal of Modern Electrophysiology

摘　　要：本文对30例经多聚酶链反应(PCR)扩增证实脑脊液中含有单纯疱疹Ⅰ型病毒的单纯疱疹病毒性脑炎进行了脑电图(EEG)、事件相关电位(P_(300))、CT、MRI检查,结果示:EEG异常率为93.33％,多表现为弥漫性异常和双额颞部异常,以非正弦形δ和θ波为主,周期性高波幅尖波的出现率为50％。16例被记录P_(300)的患者中,5例P_(300)消失、6例P_(300)潜伏期延长、5例正常。EEG、P_(300)的异常与CT、MRI的病灶部位较为一致。Objectives:To investigate the clinical features and changes of EEG and event-related potentials (P300) in patients with herpes simplex encephalitis (HSE).Methods:58 times of routine EEG were recorded in 30 patients with HSE,P300 was elicited from Fz,Cz and Pz by 'oddball paradigm'in 16 patients with HSE.Results:The abnormal rate of EEG was 93.33%,the majority of EEG showtd diffused and bilateral frontal and temporal 8 and 0 wave.the incidence of periodic synchronous discarge (PSD)was 50%.P300 disappeared in 5 patients HSE,delayed latency of P300 was found in 6 patients with HSE,P300 of 5 patients with was normal Conclusion:EEG could play an important role in the early diagnosis of HSE.The changes of P300 suggest that the temporal lobe and hippocampus play an important orle in generating the P300.

关 键 词：单纯疱疹病毒性脑炎 脑电图 事件相关电位 PCR CT MRI 

分 类 号：R512.3[医药卫生—内科学]