α,β-聚-DL-天冬酰胺修饰材料及键合阿司匹林共价复合体的合成及表征  

SYNTHESIS AND CHRACTERIZATION OF α,β-POLY-DL-ASPARAMIDE DERIVAT AND THEIR COMPLEXES CONJUGATING ASPIRIN

作　　者：周涛[1] 王斌[1] 汤谷平[1] 陈启琪[1] 

机构地区：[1]宁波大学食品工程系,浙江医科大学药学系

出　　处：《宁波大学学报（理工版）》1998年第1期61-66,共6页Journal of Ningbo University：Natural Science and Engineering Edition

基　　金：国家自然科学基金

摘　　要：以不同摩尔比的丙胺和３－氨基丙醇为侧链基，接入聚天冬酰胺，合成一系列具有不同脂溶性、水溶性的α，β－聚（丙基，３－羟丙基）ＤＬ－天冬酰胺，并以这些高分子材料为载体，以共价键键合阿司匹林，合成一系列共价复合体；并对这些材料和复合体进行表征，用紫外分光光度法测定了复合体中阿司匹林的接入率及方法回收率。A series of α,β -poly-(propyl, 3-hydrox-propyl) - DL- asparamide (PHPPA) with different solution character are synthesized by linking different ratios of propylamine and 3- amino- l - propanol to polyasparamide. Polymeric drugs (ASA-PHPPA) are synthesized by conjugating aspirin with these polymers ( PHPPA) . Polymers are characterized by infrared spectrophotometry (IR), differential scanning calorimetry( DSC), molecular weight and water absorption. polymeric drugs are characterized by IR and DSC. The aspirin loading rate in ASA-PHPPA and the recovery of ASA added are determined.

关 键 词：聚天冬酰胺 阿司匹林 高分子药物 

分 类 号：R973.2[医药卫生—药品]