肿瘤患者血清TNF-α、IL-6、IL-8检测及意义  

Detection of TNFα、IL6 and IL8 in Patients with Tumours and its Significance

作　　者：赵惠芳[1] 易忠群[1] 程新宪[1] 魏瑞全[1] 

机构地区：[1]解放军第323医院实验科

出　　处：《西北国防医学杂志》1998年第1期27-28,共2页Medical Journal of National Defending Forces in Northwest China

摘　　要：目的：研究检测肿瘤患者血清ＴＮＦ－α、ＩＬ－６、ＩＬ－８的意义。方法：应用酶联免疫法检测恶性及良性肿瘤与正常对照组病人血清中的ＴＮＦ－α、ＩＬ－６、ＩＬ－８并进行分析。结果：１１７例恶性肿瘤病人血清中３种细胞因子水平及阳性率明显高于良性肿瘤与正常对照组。３种细胞因子间进行相关分析，结果ＴＮＦ－α与ＩＬ－６水平呈显著相关（Ｐ＜０．０１），其它呈部分显著相关。结论：检测肿瘤病人血清中３种细胞因子对了解病人体内免疫状态及肿瘤发生发展有一定意义。Purpose:To study the significance of detection of serum tumour necrosis factorα(TNFα),interleukin6(IL6)and interleukin8(IL8) in patients with tumours.Methods:Detection of serum TNFα,IL6 and IL8 was made in cases with malignant,benign tumours and healthy controls utilizing ELISA method.Results:The levels and positive rates of these three serum cell factors in 117 cases of malignant tumours were higher than those in benign tumours and healthy controls.Results of correlative analysis among these three cell factors showed that there was a significant correlation between TNFα and IL6 levels(P<0.01),and there was partial correlation among the others.Conclusion:To detect these three serum cell factors is helpful for recognizing the immunologic status,the occurence and the development of tumours in these patients.

关 键 词：TNF-Α IL-6 IL-8 ELISA 

分 类 号：R446.61[医药卫生—诊断学]