急慢性肝病患者全血及血清中bcl-2的检测及其临床意义  

Detection of bcl-2 in whole blood and sera from patients with acute and chronic liver disease

作　　者：邹正升[1] 辛绍杰[1] 张占红 施红[1] 徐东平[1] 韩凤连[1] 

机构地区：[1]解放军三○二医院,北京100039

出　　处：《传染病信息》1998年第3期120-120,共1页Infectious Disease Information

摘　　要：目的:研究与细胞凋亡相关的bcl-2在急慢性肝病患者全血中存在情况及其临床意义,以及判断是否在血清中存在bcl-2;方法:选择46例患者为研究对象,其中男37例,女9例,年龄17岁～67岁,平均38.1岁。急性肝炎4例,慢性肝炎轻度8例,中度4例(慢性肝炎均经病理证实),肝炎肝硬变20例,慢性重型肝炎10例。乙型肝炎41例。In order to investigate the level ofbcl--2 (anti-apoptosis protein) in whole blood ndsera from patients with acute and chronic liverdiseases, bcl--2 in whole blood and sera asdetected from 46 patients (male, 37; female, 9)with acute hepatitis (n=4), chronic mild epatitis(n = 8), chronic moderate hepatitis (n = 4), livercirrhosis (n = 20), chronic severe epatitis (n =10) by ELISA method. The results showed that:(1) the level of bcl--2 in whole lood from patientswith acute hepatitis, chronic hepatitis, livercirrhosis and chronic severe epatitis was 146. 83±4.01、105. 47±58. 53 and 66. 91±52. 23U/ml (P<0. 05); (2) bcl-- 2 in era from patients with acuteand chronic liver diseases was undetectable. Itsuggests that cl-2 may block liver cell apoptosismediated by Fas antigen and demonstrates thatthere is o cl-2 in sera of acute and chronic liverdiseases.

关 键 词：BCL-2 病毒性肝炎 全血 

分 类 号：R446.6[医药卫生—诊断学]